RT Journal Article
SR Electronic
T1 Reduced neonatal lung function and wheezing illnesses during the first 5 years of life
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 3403
VO 38
IS Suppl 55
A1 Anne van der Gugten
A1 Cuno Uiterwaal
A1 Theo Verheij
A1 Kors van der Ent
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/3403.abstract
AB Introduction: Studies about reduced neonatal lung function and wheezing illnesses in childhood showed conflicting results. No study analyzed the association between the single occlusion technique (SOT) and wheezing illnesses during the first 5 years of life.Objectives: The aim was to assess the association between resistance and compliance of the respiratory system (Rrs, Crs) measured shortly after birth and wheezing-associated primary care consultations during the first 5 years of life, different wheezing phenotypes, and asthma at age 5.Methods: Infants participate in WHISTLER, a birth cohort on wheezing illnesses. SOT was performed during natural sleep before 2 months of age. Wheezing-associated consultations were collected from the electronic patient file. Poisson regression was used to study the association between Rrs and Crs and the number of consultations. Median Rrs and Crs values of children with different wheezing phenotypes and with and without asthma were compared by non-parametric tests.Results: 549 infants had successful SOT and complete medical files. Every kPa/l/s increase in Rrs was associated with 9% more consultations in the first 3 years of life. Every cl/kPa increase in Crs was associated with a 17% reduction of consultations in the first 3 years of life and 29% in the 4th-5th year of life. Children with late-onset or persistent wheezing and with asthma had significantly lower Crs values than their peers.Conclusion: An increased neonatal Rrs is associated with more wheezing illnesses during infancy, while a reduced neonatal Crs is associated with more wheezing illnesses during the first 5 years of life, a late-onset or persistent wheezing phenotype, and asthma at age 5.