RT Journal Article SR Electronic T1 Biomarkers in severe community-acquired pneumonia (SCAP) prognosis, complications and outcomes JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p1471 VO 38 IS Suppl 55 A1 Oksana Omelyanenko A1 Alexander Makarevich A1 Elena Amelchenko A1 Tatyana Rybina YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p1471.abstract AB Background: Early prognostic assessement is crucial for SCAP patients management.We studied accuracy of C-reactive protein (CRP), ilnterleukin-2 (IL-2), interferon-γ (IFN-γ), free triiodthyronine (fT3), free tetraiodthyronine (fT4), thyroid stimulating hormone (TSH), total cortisol (TC) in predicting SCAP hospital mortality and disease severity, outcomes, complications, need for invasive mechanical ventilation (IMV) and vasopressor support (VS).Methods: 30 ICU patients with SCAP CURB-65 class 3-5 were enrolled. Control group included 16 healthy subjects.X-ray examination,serum markers measurement were performed on the 1st day after admission.Results: CAP severity was associated with enhanced CRP (r=0,8; p<0,05), IL-2 (r=0,64; p<0,05), TC (r=0,87; p=0,01), decreased fT3 (r= -0,75; p<0,05) values. Non-survivors revealed higher CRP,IL-2, TC, lower fT3, TSH levels vs those in survivors [median: 11 vs 241mg/ml, p<0,05], [138 vs 0,8 pg/ml, p=0,03], [1377 vs 865 nmol/l, p=0,03], [2,8 vs 4,6 pmol/l, p<0,05], [0,89 vs 2,6 mMU/l, p=0,03]. Necrotising pneumonia developed in patients with decreased IL-2, fT4 values (r=- 0,6; p=0,04 and r=-0,48; p=0,03),pleural effusion - in those with enhanced IFN-γ levels (r=0,8; p=0,01). IL-2,CRP,TC values were higher in patients requiring VS [122 vs 19 pg/ml, p=0,04], [311 vs 232 mg/ml, p<0,05], [1377 vs 865 nmol/l, p=0,03]. Enhanced CRP, low fT3 levels were associated with IMV requirement (r=0,63; p<0,05 and r=-0,71; p<0,05). Duration of ICU stay correlated with TC, CRP values (r=0,89; p=0,01 and r=0,43; p=0,04),length of hospitalisation - with TSH, fT4 levels (r= 0,56; p=0,01 and r= -0,44; p=0,05).Conclusions: CRP, thyroid hormone, TC, IL-2, IFN-γ can augment early prognostic assessment of SCAP pts.