PT  - JOURNAL ARTICLE
AU  - Desmond Cox
AU  - David Mullane
AU  - Steven Turner
AU  - Guigeng Zhang
AU  - Catherine Hayden
AU  - Jack Goldblatt
AU  - Lou Landau
AU  - Peter Le Souef
TI  - Associations between bronchiolitis and respiratory outcomes at 18 years in the PIAF birth cohort
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1170
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p1170.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p1170.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Introduction: The Perth infant asthma follow-up (PIAF) study is a birth cohort of unselected subjects who have undergone longitudinal respiratory assessments from birth to 18 years. We previously reported that individuals with bronchiolitis had reduced lung function and increased wheeze in later childhood. We also found that there was reduction in lung function in individuals both before bronchiolitis and at 11 years of age.Aim: To investigate the relationship between bronchiolitis and respiratory outcomes in early adulthood.Methods: Children had prospective assessments performed at 1, 6 and 12 months and again at 6, 11 and 18 years. They included a questionnaire, lung function, airway responsiveness and skin prick testing.Results: The initial recruitment population was 253. We followed up 150 children at 18 years, of which 20 had current asthma and 13 had persistent asthma. There were 16 cases of confirmed bronchiolitis previously identified. We found a significant association between bronchiolitis and “ever being diagnosed with asthma” (p=0.01, OR 7.35, 95%CI 1.5 to 35.0) and “ever being diagnosed with asthma” (p=0.03, OR 5.1, 95%CI 1.1 to 23.2) at 18 years. Children diagnosed with bronchiolitis had a mean reduced FEF of 16% (95% CI;-1.4 to -0.8, p=0.03) when compared to rest of the cohort at 18 years.Conclusion: These data confirm that the reduced flows at 1 month and 11 years were not fortuitous and suggests that this group have airways that predisposed to bronchiolitis in infancy, increased asthma in childhood, no increase in active symptoms in early adult life but will need follow up to see if they are prone to conditions such as COPD or tobacco related lung disease.