RT Journal Article
SR Electronic
T1 The pattern and timing of breathing during graded exercise test in systemic lupus erythematosus
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p1542
VO 38
IS Suppl 55
A1 Danilo Marcelo Prado
A1 Renata Miossi
A1 Fernanda Lima
A1 Bruno Gualano
A1 Hamilton Roschel
A1 Eduardo Borba
A1 Eloisa Bonfa
A1 Ana Lucia Sá Pinto
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p1542.abstract
AB Background: Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease that affects all organs including the respiratory system. Abnormal control of breathing during maximal voluntary ventilation has been recently identified in this disease.Purpose: To evaluate the pattern and timing of breathing at selected submaximal ventilatory stress in SLE.Methods: Twenty consecutive women (age: 28.8±1.0 years) with SLE were selected and compared to an age and BMI matched group of 19 healthy women (CTRL) (age: 26.2±1.3 years). All of the subjects performed a progressive treadmill cardiopulmonary test until exhaustion. Data were analyzed at absolute isoventilation (40, 60 and 80 L/min).Results: SLE presented lower relative aerobic fitness (VO2peak) (26.8±1.2 vs. 35.9±1.2 mL kg-1 min-1, p=0.001) than their healthy peers.View this table:Ventilatory parameters at different absolute isoventilationConclusion: These results demonstrated a thachypnoeic breathing pattern and shorter timing of ventilation in SLE woman during exercise. This suggests that the reduced aerobic capacity observed in SLE patients may be accompanied by ventilation-perfusion mismatches.