TY - JOUR T1 - Non-invasive evaluation in prediction of pulmonary hypertension in patients with idiopathic pulmonary fibrosis JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2364 AU - František Salajka AU - Vladimír Bartoš AU - Jakub Novosad AU - Josef Štásek AU - Josef Bis AU - Miroslav Brtko AU - Pavel Polanský AU - Vladimír Koblízek AU - Vratislav Sedlák Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2364.abstract N2 - Pulmonary hypertension (PH) occurs rather frequently in patients with advanced idiopathic pulmonary fibrosis (IPF). However, no reliable non-invasive screening method of detection is available so far. Recently, new formula allowing to detect the patients with PH among patients with IPF and, also, to assess the mean pulmonary artery pressure (MPAP) in individual patients was published: –11.9 + 0.272 × SpO2 + 0.0659 × (100 – SpO2)2 + 3.06 × FVC%/TLCO% [1]. The aim of our study was to confirm the usefulness of this formula in our group of IPF patients.In a prospective study, lung function tests and right heart catheterization examinations were performed in a group of 27 patients with IPF. In total, pulmonary hypertension (MPAP > 20 mm Hg) was detected by catheterization in 17 patients (63%). Compared with the results of the formula, the significant correlation was not reached either for the PH defined according to the recent recommendation (MPAP > 20 mm Hg, r=0.135, p=0.502). or when the border level criterion for PH was heightened to 25 mm Hg, similar to the originally published data (r= -0.043, p=0.833). Also, the use of the tested formula to calculate the level of MPAP in individual patients was not helpful. We found only a non-significant correlation between the level of the mean cMPAP and the calculated MPAP in individual patients (r= -0.148, p=0.461).In conclusion, our study did not confirm the possibility of using the published formula to predict with sufficient accuracy either the presence or the level of PH in patients with IPF.Reference:1. Zisman DA et al. Prediction of pulmonary hypertension in idiopathic pulmonary fibrosis. Respir Med 2007;101(10):2153–2159. ER -