RT Journal Article
SR Electronic
T1 Safety and efficacy of pleurodesis with thoracoscopic doxycycline poudrage in malignant pleural effusion
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3557
VO 38
IS Suppl 55
A1 Mohamed Elnady
A1 Amr Sakr
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3557.abstract
AB Objective: To assess the safety and efficacy of thoracoscopic doxycycline poudrage (TDP) for pleurodesis in malignant effusions.Design: Retrospective.Methods: Twenty seven patients were included in this study. Thoracoscopy was performed for diagnosis and subsequent doxycycline pleurodesis. At the end of thoracoscopy, a new method for Doxycycline delivery to the pleura was used through pneumatic atomizer insufflations where about 500-1000 mg of doxycycline were taken & prepared as a powder from the oral preparation (vibramycin 100 mg/capsule).Results: 74.1% had a successful pleurodesis, 18.5% had partial reponse and 7.4% had failed pleurodesis at one month. Adverse effects included pain (48.1%), fever (3.7%) and pain & fever (22.2%). The mean drainage time for intercostals tube was about 1.52 days.Conclusions: TDP is an inexpensive, well tolerated, reasonably effective, comparatively simple, safe, and capable of alleviating respiratory symptoms.