TY - JOUR T1 - Comparison of multidimensional assessment systems with regard to risk prediction for exacerbations of COPD JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p556 AU - Takashi Motegi AU - Takeo Ishii AU - Kumiko Hattori AU - Koichiro Kamio AU - Kouichi Yamada AU - Misuzu Kurahara AU - Akihiko Gemma AU - Kozui Kida Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p556.abstract N2 - Aim: Acute Exacerbations of COPD (AECOPD) are major concerns with regard to morbidity, mortality and economic burden. In this study, we compared the efficacy of 3 assessment systems for predicting AECOPD: BODE index (Body mass index, airway Obstruction, Dyspnea, Exercise capacity); DOSE index (Dyspnea, airway Obstruction, Smoking status, Exacerbations); and ADO index (Age, Dyspea, airway Obstruction).Participants and methods: The frequency of exacerbations (FE) for a 1-year period was retrospectively studied for 183 consecutive patients with COPD. Following parameters were used to compare the results: pulmonary function tests, 6-minute walking test, MMRC dyspnea scale, low-attenuation area (LAA%) on HRCT and FE.Results: The study included 183 patients (M/F 170/13). The mean age and FEV1%predicted were 71.4 years and 55.7%, respectively. The mean annual exacerbation rate was 0.57 per patient-year. FE was significantly correlated with the following parameters: lower FEV1%predicted (p<0.001), lower% DLco/VA (p=0.021), shorter 6MWD (p=0.016), higher MMRC (p=0.001), higher DOSE index (p<0.001), higher BODE index (p=0.001), higher ADO index (p=0.001), and larger LAA% (p=0.002). FE was significantly associated with prescribed long-term oxygen therapy (Odds ratio [OR] 4.17, p < 0.001) and exacerbation rate for the previous year (OR 2.79, p < 0.001). The area under the receiver-operator curve for predicting exacerbation during the 1-year follow-up was 0.65 for the BODE index, 0.64 for the ADO index, and 0.75 for the DOSE index.Conclusions: The DOSE index appears to be superior to the BODE and ADO indices interms of predicting exacerbations of COPD. ER -