PT - JOURNAL ARTICLE AU - Oleksander Katilov AU - Dmytro Dmytriiev AU - Oleksander Mazulov TI - Clinical management and outcome of childhood lung abscess (LA): A 15-year experience DP - 2011 Sep 01 TA - European Respiratory Journal PG - p1156 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/p1156.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/p1156.full SO - Eur Respir J2011 Sep 01; 38 AB - In order to evaluate the clinical manifestations, management and outcome of childhood LA, a retrospective chart review of 35 pediatric with LA from Semtember 1995 to Semtember 2010 was conducted. Among the 37 patients (20 males and 15 females), 51, 4% (18/37) were primary lung abscess and 49,6% (17/35) had underlying chronic diseases (secondary lung abscess). The predisposing factors of the primary group (n = 18) included 16 cases of respiratory tract infection and 2 with laceration wound. The underlying diseases in the secondary group (n = 17) included 11 cases of hematologic disorder (64,7%), 4 of congenital heart disease, and 2 each of hyperimmunoglobulin E syndrome. 14 patients underwent diagnostic tapping, including echo-guided aspiration (11 cases) and computed tomography-guided percutaneous needle aspiration (2 case). Positive yield rate from aspiration of lung abscess was 50% (7/14). Surgical intervention was performed in 10 of the secondary group and in 1 patient from the primary group. The pathogens were identified in 17 patients (49,6%): 5 with oral flora, 4 with Staphylococcus aureus plus other pathogens, 1 with S. aureus alone, 2 with Pseudomonas aeruginosa plus Proteus mirabilis, 4 with P. aeruginosa alone, and 1 with Aspergillus. The average duration of parenteral antibiotic use was 20 days. 2 cases (5.4%) died due to poor control of the underlying diseases, and 4 of the patients (10,8%) had sequelae (3 with bronchiectasis and 1 with lung fibrosis). Early percutaneous aspiration has an important role in identification of pathogens. Oral anaerobes and S. aureus are the core pathogens in primary lung abscess and gram-negative pathogens should also be considered in secondary LA.