RT Journal Article
SR Electronic
T1 Inhibiting effects of tiotropium bromide on neocollagenesis during 6 month treatment
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p535
VO 38
IS Suppl 55
A1 Mykola Ostrovskyy
A1 Oleksandr Varunkiv
A1 Mariana Kulynych-Miskiv
A1 Iryna Savelikhina
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p535.abstract
AB Background: Chronic obstructive pulmonary disease (COPD) is one of the most important causes of morbidity and mortality worldwide, which are the third most common cause of death (8%) in the 25 member states of the European Union.Purpose of the study: Is the evaluation of type IV collagen dynamic in bronchoalveolar lavage (BAL) during the treatment with tiotropium bromide.Materials and methods: The content of type IV collagen was investigated in BAL of 43 patients with stage 2 COPD before and after 1, 3 and 6 months of treatment with tiotropium bromide using ELISA.Results of the study: The content of type IV collagen in BAL on a moment of hospitalization in patients with COPD exacerbation was (61,14±1,28) ng/ml that is in 6.19 times (p<0,05) higher than in healthy. In patients with COPD exacerbation treated within 1 month with integrated treatment including tiotropium bromide as a basic therapy we identified the reduction of type IV collagen levels in 1.41 times in BAL compared with data before treatment. We found further positive trends - reduction of type IV collagen on 79.4% with using tiotropium bromide within 2 months. The level of type IV collagen in bronchoalveolar fluid dropped in 2.23 times (p<0.05) compared with the level before treatment. We identified practically complete normalization of type IV collagen levels in BAL only during 6-month of tiotropium bromide admission in patients with stage 2 COPD. This rate was higher only at 29.8% (p <0,05) comparing with healthy.Conclusions: The reduction of type IV collagen content in BAL under tiotropium bromide treatment during 6 month is a clear evidence of inhibiting effects of tiotropium bromide on neocollagenesis