@article {Pavlenkop1079, author = {Irina Pavlenko and Julia Ilkovich and Nina Shklarevich}, title = {Influence of smoking intensity and smoking quitting on lung function parameters in COPD patients}, volume = {38}, number = {Suppl 55}, elocation-id = {p1079}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Aim: To evaluate dependence of changes in lung function parameters (LFP) from intensity of smoking in patients with moderate and severe COPD.Materials, methods: 74 patients (63 male, 11 female) with COPD III-IV stages, receiving therapy according to GOLD. The mean smoking status - 36,5 pack years (p/y). The patients were divided into 2 groups: 1. Current smokers (43 pts., 37 male), mean age - 60{\textpm}13.5 years; smoking status - 39,9 p/y; average 19 cigarettes per day. 2. Ex-smokers (31 pts., 26 male), mean age- 62.19{\textpm}14,5 years, smoking status - 31{\textpm}27 p/y. Each group was divided to 2 subgroups: low smoking intensity (0 - 20 cigarettes per day) and high smoking intensity (20 and more cigarettes per day). LFP (FEV1 in liters, FEV1/FVC\% of pred., {\textquotedblleft}Lung Age{\textquotedblright} - LA) were analyzed in groups during one year. LA was estimated according to Morris JF and Temple W (Prev Med 1985;14:655-662).Results: LFP significantly improved in a year in ex-smokers vs. current smokers (p\<0,01). FEV1 and LA significantly improved (p<=0,05) in ex-smokers vs. current smokers in subgroups with low smoking intensity. FEV1 significantly improved in ex-smokers vs. current smokers in subgroups with high intensity of smoking.Conclusion: Smoking sessation has positive influence on lung function parameters in patients with severe and moderate COPD irrespectively of smoking intensity. FEV1 in litres is the most sensitive indicator reacting on smoking intensity.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p1079}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }