PT  - JOURNAL ARTICLE
AU  - Amandine Vial-Dupuy
AU  - Olivier Sanchez
AU  - Liath Guetta
AU  - Benoit Douvry
AU  - Karine Juvin
AU  - Delphine Wermert
AU  - Emmanuel Guerot
AU  - Dominique Israel-Biet
TI  - Outcome of patients with interstitial lung disease admitted into ICU
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - 4862
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/4862.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/4862.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: Limited data are available on the clinical course of patients with Interstitial Lung Disease (ILD) and acute respiratory failure requiring admission to ICU.Objectives: To investigate the outcome of patients with ILD and acute respiratory failure with special attention to Idiopathic Pulmonary Fibrosis (IPF) or Drug-induced ILD (DI-ILD).Methods: Retrospective identification of patients with ILD admitted into ICU between 1993 and 2009. Primary end-point was in-hospital mortality.Results: 72 subjects could be included, divided into 3 groups: IPF, n=28; DI-ILD, n=20 and Miscellaneous, n=24. The in-hospital mortality rates were 68, 40 and 25% for IPF, DI-ILD and Miscellaneous, respectively, (p=0.006) and reached 100, 64 and 60%, respectively, in those receiving mechanical ventilation (p=0.007).On multivariate analysis, the need for invasive or non invasive ventilation (OR= 35; [95% IC, 5-255]), the type of ILD (IPF vs Miscellaneous) (OR=22; [95% IC, 3-147]), and high-dose steroids during ICU stay (OR=0.19; [95% IC, 0.04-0.99]) were found to be independent determinants of in-hospital mortality.Conclusion: This study highlights the poor prognosis of IPF in ICU particularly if mechanical ventilation is required. DI-ILD and Miscellaneous with comparable severity criteria have a better prognosis than IPF. High-dose steroids appear as a protective factor whatever the type of ILD.