PT  - JOURNAL ARTICLE
AU  - Judy Pitts
AU  - Shahid Sheikh
AU  - Karen McCoy
TI  - Safety and efficacy of omalizumab in children with allergic asthma
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p4826
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p4826.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p4826.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: Omalizumab (Xolair) is a humanized monoclonal antibody used in the treatment of adults and children over 12 years with moderate to severe allergic asthma. Pediatric studies are few.Objective: A retrospective chart review of pediatric patients who received omalizumab in the past 10 years for asthma at Nationwide Children's Hospital, Columbus, Ohio.Results: We had 13 patients, M:F 7:6, median age 13 years (range 9-17), median duration of therapy 36 months (range 1 to 59 months), 9 African American and 4 Caucasian, duration of asthma 15 years (8 to 16). Eight are still on therapy. All patients had severe persistent asthma. Twelve patients were receiving combination therapy (ICS and LABA). Only 4 patients claimed compliance with their asthma controller therapy. Five had family history of asthma, 6 had smoking exposure. Median IgE before starting omalizumab was 249 (range 78 to 2600). Mean BMI was 25.7 and 46% of the patients were above the 100 percentile for BMI. Comparing between one year before and during omalizumab, mean hospital admission/patient/year decreased from 1.7±2.4 to 0.58±1.4 (p<0.05). There was also a trend towards improvement in ED visits from 2.3±3.2 to 1.7±3. Mean FEV1 during one year before omalizumab therapy, at initiation of therapy and during therapy was 91±18, 94±17, and 93±11 and was not statistically different.Two of 13 patients were taken off omalizumab because of serious side effects, one with anaphylaxis and second with dilated cardiomyopathy. Anaphylaxis was noted on first dose and cardiomyopathy was diagnosed in 5th year on therapy.Conclusion: Omalizumab is add-on therapy for some patients with allergic asthma. Adverse reactions in children are limiting factor.