TY - JOUR T1 - Laboratory investigation of sputum and mucociliary clearance (MCC) condition in patients with COPD JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4047 AU - Tetyana Pertseva AU - Olena Lykholat AU - Olena Gurzhiy Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4047.abstract N2 - Aim: To investigate biochemical parameters of sputum for evaluation of MCC's disorders in patients with COPD.Materials: 90 smoking patients with COPD in stable condition.Methods: Biochemical parameters of sputum (medium weight molecules (MWM), trypsin, cysteine proteases cathepsin B, cathepsin L, α1-proteinase inhibitor (α1-PI)) were researched for MCC's evaluation.Results: Dynamics of indices are in table 1.View this table:Table 1Conclusions: Bronchial obstruction progression accompanied by decreasing of local proteolytic potential of sputum: trypsin (r= -0,61, p<0,001); cathepsin B (r= -0,42, p<0,01); cathepsin L (r=0,39, p<0,01); α1-PI (r=0,39, p<0,01). It leads to decreasing of sputum lysis and accumulation of hyperviscosity mucus in respiratory tract. As a result, movement of ciliary epithelium is blocked.Decreasing of sputum lytic properties accompanied by accumulation of MWM (correlation between severity of COPD and MWM level – r=0,60, p<0,001). It also enhances the viscosity of sputum and violates the optimal conditions of MCC functioning.So, bronchial obstruction progression in patients with COPD accompanied by decreasing of common lytic activity of sputum, therefore excessive amount of viscous bronchial secretion accumulate. It slows down ciliary epithelium movement, compounding the disorders of MCC. ER -