PT  - JOURNAL ARTICLE
AU  - Dina Petrova
AU  - Yakov Shoikhet
AU  - Andrei Dorokhov
AU  - Sergei Berestov
TI  - Features of pulmonary involvement in patients with diffuse connective tissue diseases depending on a nosological form
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p644
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p644.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p644.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - The objective is to study features of pulmonary involvement in patients with diffuse connective tissue diseases (DCTD) depending on a nosological form.Materials and methods: Retrospective cohort study of 1363 patients with DCTD. Exclusion criteria: concomitant bronchopulmonary pathology, malignant neoplasms. Standard clinical examination, electrocardiography, echocardiogram, spirometry, X-ray study, high resolution computed tomography, ultrasonic scanning of pleura were made.Results: The involvement of respiratory system was found in 56 (4,11%) of 1363 examined patients. The patients with systemic lupus erythematosus (SLE) - 25 (44,6%), rheumatoid arthritis (RA) – 19 (33,9%) and systemic scleroderma (SS)- 9 (16,1%) prevailed.In SLE patients pulmonary involvement was commonly manifested by lupus pleuritis (36,0%), pneumonitis (28,0%), bronchoobstructive syndrome (12,0%), pulmonary hypertension (8,0%) and diffuse interstitial pulmonary fibrosis (4,0%). In three patients (12,0%) various combinations of pleuritis, pneumonitis, bronchoobstructive syndrome and signs of interstitial diffuse pulmonary fibrosis were diagnosed. In RA patients, in 100,0% of cases the involvement of respiratory system included bronchoobstructive syndrome manifestations, while in SS patients– fibrosing avleolitis.Conclusion: In 100,0% cases the involvement of respiratory system with bronchoobstructive syndrome manifestations was more characteristic for RA patients, while for SS patients– fibrosing avleolitis. Pulmonary involvement in SLE patients is more heterogeneous, presented by pleuritis, pneumonitis, bronchoobstructive syndrome and their combinations.