PT - JOURNAL ARTICLE AU - Hyun Kim AU - Matthew Brown AU - Fereidoun Abtin AU - Peiyun Lu AU - Daniel Chong AU - Jonathan Goldin TI - Association of texture-based quantitative fibrotic patterns and pulmonary function test in a new validation set DP - 2011 Sep 01 TA - European Respiratory Journal PG - 1440 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/1440.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/1440.full SO - Eur Respir J2011 Sep 01; 38 AB - Background: Under non-volumetric CT scan, a texture-based quantitative lung fibrosis (QLF) score has been developed as a computer-aided diagnostic metric in a scleroderma-related interstitial lung disease (SSc-ILD) [1].Objective: To test an association the QLF from CT score with pulmonary function tests in new study cohort.Methods: From our anonymized research database, 119 subjects with SSc-ILD (mean age 48±10.6 years and 70.7% ±14.3 of FVC) underwent baseline CT scans with high-resolution, volumetric, 64 detectors in the prone position at full inspiration. The extents of fibrotic patterns were measured as a QLF score in 5 steps: 1) denoise images; 2) grid-sample at a fixed location; 3) convert the characteristics of intensities into texture features; 4) classify voxels as fibrotic or non-fibrotic patterns based on texture features and 5) report fibrotic voxels as percentages. Associations were tested by Spearman rank correlation.Result: Correlations between pulmonary function test and QLF were similar in the previous study and this new cohort as shown below.View this table:Correlation between QLF and pulmonary function testConclusion: The quantitative fibrotic patterns in whole lung can be a useful prognostic metric of severity and the heterogeneity of distribution in fibrotic patterns in lobes can be used as an index.Reference:1. Kim HJ, Tashkin DP, Clements PJ, et al. A computer-aided diagnosis system for quantitative scoring of extent of lung fibrosis in scleroderma patients. Clin Exp Rheumatol. 2010 (5 Suppl 62); S26-35.