PT  - JOURNAL ARTICLE
AU  - Giulia Innocenti Bruni
AU  - Francesco Gigliotti
AU  - Claudia Coli
AU  - Barbara Binazzi
AU  - Ilenia Presi
AU  - Isabella Romagnoli
AU  - Barbara Lanini
AU  - Loredana Stendardi
AU  - Giorgio Scano
TI  - Exercise-related perceptions do not affect exercise response in subjects with OSA
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p2143
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p2143.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p2143.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Lean and obese subjects have similar exercise capacity and intensity of dyspnea and leg effort. Obese individuals with OSA have a reduced exercise capacity (Vanhecke 2008); if this depends on exercise-related perceptions needs to be defined. Sixteen subjects with OSA, 8 lean (BMI:25.6±2.5) and 8 obese (BMI:40.8±10.1) and 14 subjects without OSA, 8 obese (BMI 44.9±7.5) and 6 lean subjects (25.5±1.9) underwent spirometry, polysomnography, and incremental exercise test. FRC (% pv) was similar in obese with and without OSA (84.4±9.8 vs 88.6±24.2 respectively; p:ns). The severity of OSA (AHI:51.1±24 vs 30.3±10.5; p:ns) was the same in obese and lean subjects. At VO2Peak (l/min: 2.62±0.6; 2.4±0.7; 2.51±0.6; 2.25±0.5 in obese with OSA and non OSA, and lean with OSA and non OSA subjects, respectively; ANOVA: p:ns). VO2peak (ml/kg/min) was similar between obese subjects (OSA vs non OSA) and between lean subjects (OSA vs non OSA). End-expiratory-lung-volume (EELV) decreased in lean subjects with (290±420ml), and without OSA (330±184ml), while increased in Obese with (270±330ml) and without OSA subjects (304±330ml). Peak BORG was similar (ANOVA p:ns) in the four groups (7.5±1.6; 6.25±1.75; 5.9±2.4; 6.8±2.3 for obese OSA and non OSA, and lean OSA and non OSA subjects, respectively). Peak leg effort did not significantly differ in obese and lean subgroups: (8.63±1.69; 7±1.9; 7.1±2.1; 8.5±0.8 for obese with and without OSA, and lean with and without OSA, respectively; ANOVA p:ns). The qualitative difference in EELV response indicates respiratory mechanical limitation during exercise in obese subjects with and without OSA. Exercise-related perceptions do not affect exercise response in obese with OSA.