%0 Journal Article %A Joanna Domagala-Kulawik %A Julita Stepien %A Grazyna Hoser %A Ryszarda Chazan %T Proinflammatory cytokines in induced sputum and COPD phenotype %D 2011 %J European Respiratory Journal %P p726 %V 38 %N Suppl 55 %X Chronic obstructive lung disease (COPD) does not have a uniform clinical and morphological nature. Airflow limitation is caused by inflammation and parenchymal destruction, there are patients with predominance of emphysema and those with predominance of chronic bronchitis. The aim of the study was to characterize the inflammatory process in two distinct forms of COPD.35 COPD patients were investigated. They were divided into two groups: emphysema (E, n=25) and chronic bronchitis pts (CB, n=10); the presence of emphysema in HRCT and hyperinflation in pletysmography were the distinguishing criteria. The concentration of cytokines (IL-8, IL-1β, IL-6, IL-10, TNFα and IL-12) in induced sputum (IS) was measured using flow cytometry with Cytometric Bead Array method.The median concentration of proinflammatory cytokines (IL-8, IL-6, IL1β and TNFα) did not differ between two groups. The concentration of IL-10 and IL-12 was slightly, but not significantly, higher in the E when compared with CB group (median: 57 vs 41 pg/mL, 1553 vs 1122 pg/mL, respectively). There was a significant correlation between the concentrations of IL-8, IL-6, IL1β and TNFα in the CB group.When we analysed the relation of cytokine concentration with the clinical parameters, we observed a difference between the E and CB group. There was a significant correlation of IL-10, TNFα and IL-12 concentration with the degree of emphysema (RV, TLC, Raw) and FEV1 only in the E group. A significant correlation of IL-6 concentration with pack/years, TLC and with the inflammatory cell total count was observed only in the CB group.The differences in cytokine profile and correlations indicate a possible different character of inflammation in two COPD phenotypes. %U