TY - JOUR T1 - Do infants with bronchiolitis get any benefit with nebulized salbutamol? JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4273 AU - Elpis Hatziagorou AU - Vasiliki Avramidou AU - Fotis Kirvassilis AU - Antigoni Mavroudi AU - John Tsanakas Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4273.abstract N2 - Background: The results of nebulized salbutamol in hospitalized infants with bronchiolitis are controversial. Rint is a standardized method of evaluation of airways broncho-constricion in infants.Aim: 1). To compare expiratory interrupter resistance (Rint) among 19 infants with bronchiolitis and 21 healthy controls. 2). To assess the effect of nebulized salbutamol on Rint among infants with bronchiolitis.Methods: Nineteen infants with bronchiolitis and positive history of atopy, family history of asthma and high total serum IgE levels were studied. Twenty one age-matched healthy infants were used as controls. Expiratory interrupter resistance (Rint) was measured before and 20 minutes after nebulized salbutamol.Results: 19 infants with bronchiolitis (mean age 9.25±6.34 months, 57% boys) and 21 age-matched healthy control infants were studied. 90.1% of them had eczema and 18.2% of them had milk allergy. Mean total serum IgE was 180.4±33.5 IU/ml. 82% of them had siblings with asthma, while 55% of them had a history of maternal asthma. As compared to controls, infants with bronchiolitis had significantly higher Rint, (2.64±0.0.78 vs 1.26±0.12 kPa L-1 second, p<0.001). Moreover, Rint was reduced significantly after administration of salbutamol; mean difference (95% confidence interval): -0.49 (-0.92, -0.06) (p = 0.028).Conclusions: Infants with bronchiolitis, positive family history of asthma and positive personal history of atopy might benefit from nebulized salbutamol, as shown by the improvement of Rint values. ER -