RT Journal Article SR Electronic T1 The relationship between comorbidities and systemic inflammation in patients with COPD JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p4057 VO 38 IS Suppl 55 A1 Ali Kocabas A1 Gulsum Tezcagirir A1 Gulsah Seydaoglu A1 Ezgi Ozyilmaz YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p4057.abstract AB Objectives: Although the effect of comorbidities on morbidity and mortality of COPD is better understood, the discussion about the role of systemic inflammation on development of comorbidities is going on. We aimed to investigate the relationship between systemic inflammation and comorbidities in patients with COPD.Methods: Comorbidities, systemic and local inflammation markers were investigated in 50-stable COPD patients and 42-healthy adults who admitted to our out-patient clinic. Venous blood samples for markers of systemic inflammation (CRP,fibrinogen,AAT, TNF-α, sTNF-R, IL-1, IL-6, IL-8, neutrophils,lymphocytes,eosinophils) and induced sputum samples for local inflammation markers (TNF-α, IL-6, neutrophils, lymphocytes, eosinophils) were examined.Results: At least one comorbidity was determined in 80% of patients with COPD and 47.6% in the controls. The depression, cachexia, pulmonary hypertension and prevalence of coronary artery disease in patients with COPD were higher than the controls (p<0.05).All markers of systemic inflammation and local inflammation, except serum mean IL-6 level and mean percentage of peripheral blood eosinophils, were significantly found higher in patients with COPD. In addition, the mean serum TNF-α and IL-8 levels were found to be associated with presence of comorbidity in patients with COPD. The determined comorbidities which are anxiety, depression, anemia, heart disease, osteoporosis and metabolic syndrome were found to be associated with one or more systemic inflammatory markers.Conclusion: The observed comorbidities in COPD is closely related to systemic inflammation however we think that the exact mechanism of each comorbidity needs to be further investigated.