%0 Journal Article %A Olga Moldovan %A Daniela Homorodean %A Elmira Ibraim %A Monica Bendorf %A Cristian Popa %T The results of drug resistance survey of MDR-strains on second line drugs obtains in national reference laboratory – “M.Nasta” Institute, Bucharest %D 2011 %J European Respiratory Journal %P p2611 %V 38 %N Suppl 55 %X Objectives: To evaluate resistance of MDR strains to the second line drugs – Kanamycin and Ofloxacine and XDR-TB among patients MDR-TB.Materials and methods: In 1 octombrie 2009-31 ianuarie 2010 was included in this study 419 patients 53 new and 366 previously treated cases which had positive cultures with MDR strains. The testing of this MDR strains was performed by indirect method of proportion to second line drugs for critical proportion 1%.Results: 1.For new cases results showed the confirmation of MDR strains 8,83%; resistant to INH+RMP+KM 2,63%; resistant to INH+RMP+OFX 0,24.% and XDR strains 0,95%.2. For previously treated cases results showed the confirmation of MDR strains 49,64%; resistant to INH+RMP+KM 22,20%; resistant to INH+RMP+OFX 7,16% and XDR strains 8,35%.Conclusions: 1.The high percentage of MDR strains of previously treated cases-49,64% is due to large number of patients provide from our Excellence Center of MDR TB.2.The percentage of XDR strains from MDR strains is 9,31%. %U