PT  - JOURNAL ARTICLE
AU  - Eva Becker
AU  - Stefan Karrasch
AU  - Holger Schulz
AU  - Sven Gläser
AU  - Christa Meisinger
AU  - Margit Heier
AU  - Annette Peters
AU  - H.-Erich Wichmann
AU  - Jürgen Behr
AU  - Rudolf Maria Huber
AU  - Joachim Heinrich
TI  - High blood pressure, antihypertensive medication and lung function in a general adult population
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p1021
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p1021.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p1021.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: Several studies showed that blood pressure and lung function are associated. Additionally, potential effect of antihypertensive medication, esp. beta-blockers, on lung function has been discussed. However, side effects of beta-blockers have been investigated mainly in patients with already reduced lung function. Thus, we aimed to determine whether hypertension and antihypertensive medication have an adverse effect on lung function in a general adult population.Methods: Within the population-based KORA F4 study 1319 adults aged 40-65 years performed lung function tests and blood pressure measurements. Information on medical history and use of antihypertensive medication was available, too. Multivariate regression models were applied to study the association between blood pressure, antihypertensive medication and lung function.Results: High blood pressure as well as antihypertensive medication were associated with lower FEV1 (p=0.02 resp. p=0.05; R2: 0.65) and FVC (p=0.01 resp. p=0.05, R2: 0.73). Furthermore, a detailed analysis of antihypertensive medication pointed out that use of beta-blockers was associated with reduced lung function, whereas other antihypertensive medication had no effect on lung function. The adverse effect of beta-blockers was significant for FVC (p=0.03; R2: 0.65), while for FEV1 the association was of borderline significance (p=0.07; R2: 0.73).Conclusion: Our analysis indicates that both high blood pressure and antihypertensive treatment are associated with reduced lung function in a general adult population. Furthermore, we speculate that the negative effect of antihypertensive medication on lung function is mainly attributable to beta-blockers.