TY - JOUR T1 - Sputum biomarkers in stable COPD JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p705 AU - Imre Barta AU - Balazs Antus Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p705.abstract N2 - Characterization of the COPD proteome could help early diagnosis of the disease and aid the development of specific treatment options. The aim of this study was to detect sputum biomarkers characteristic for COPD.Induced sputum was collected from 19 stable COPD patients (GOLD I-III, ex-smokers, mean age 62 years, pack year 52, FEV1 64% predicted, FEV1/FVC 50%) and 19 healthy controls (mean age 62 years, pack year 29, FEV1 110% predicted, FEV1/FVC 77%). CRP level (9.8mg/L vs. 5.1mg/L) and total sputum cell number (3.5×106 vs. 1.3×106) were significantly different between the two groups.Sputum supernatants were subjected to cytokine antibody microarray analysis. Of the 120 cytokines investigated 96 was detectable above background level in the majority of samples. A greater subset of factors was down regulated while a smaller subset was up regulated in COPD. 14 cytokines exhibited a difference of at least 50% in relative expression level. IL-6, IL-1α, GRO and GROα expression was significantly different (p<0.05) in COPD patients vs. healthy controls. These results suggest that a CODP specific cytokine pattern might exist. ER -