%0 Journal Article %A Maria N. Akulova %A Svetlana I. Ovcharenko %A Emma N. Ishchenko %T Is it possible to decrease asthma severity by use of antidepressants? %D 2011 %J European Respiratory Journal %P p523 %V 38 %N Suppl 55 %X Aim: To evaluate influence of asthma control including antidepressant fluvoxamine on asthma severity.Methods: 42 patients with uncontrolled asthma were included into the study (23 men, age 25-71 years). 16 patients had hysterical depression, 12 patients - anxious-hysterical disorders and 14 - neurosis. Fluvoxamine 100-300 mg/daily (mean dose 200 mg/daily) was added for 6 weeks to complex asthma therapy (ICS and LABA in therapeutical doses) according to severity of asthma. Asthma control was evaluated twice in accordance with GINA criteria at baseline and after 6 weeks of treatment. Tolerability and safety was evaluated by side effects registration, change in initial asthma symptoms and laboratory data. Severity of depression and level of anxiety was evaluated by means of Hospital Anxiety and Depression Scale (HASD).Results: We observed significant improvement of spirometry parameters and asthma control after adding of fluvoxamine to complex asthma therapy. In most of the patients asthma was evaluated as controlled (19,1% - 8 patients) and partly controlled (47,6% - 20 patients). In 14 patients (33,3%) asthma was not controlled. These patients had combination of mental disorders. Significantly decreased score of depression (from 13,4 to 2,1) and anxiety (from 13,9 to 2,8) by HASD was also observed.Conclusions: Complex asthma therapy including antidepressant (fluvoxamine) improves asthma control and has an evidence of high efficacy. %U