@article {Talinip4942, author = {Donatella Talini and Federica Novelli and Elena Bacci and Maria Laura Bartoli and Silvana Cianchetti and Federico Lorenzo Dente and Antonella Di Franco and Lorenza Melosini and Pierluigi Paggiaro}, title = {FEV1 decline and eosinophilia in occupational asthma}, volume = {38}, number = {Suppl 55}, elocation-id = {p4942}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Background: There are few informations available on how rapidly lung function declines in subjects with occupational asthma (OA) who continue to be exposed.Subjects and methods: FEV1 was monitored in 38 subjects with OA (age 41.9{\textpm}11.7 yrs, 4 smokers and 19 ex-smokers). 16 (44.1\%) were exposed to high molecular weight compounds (HMWC) and 22 (57.9\%) to low molecular weight compounds (LMWC), with an occupational exposure of 16.0 (range: 1-45) yrs. We used simple regression analysis to provide estimates of the decline in FEV1 during the period of occupational exposure 4.1 (range 1.2-13.7) yrs. The mean rate of change in FEV1 was -32.9 (range: -217.31-426.2) ml/yr.Results: In all subjects FEV1 decline was significantly worse (p=0.04) in subjects with higher eosinophilia (\>3\%), but there wasn{\textquoteright}t difference between subjects exposed to LMWC or HMWC nor respect to the use of inhaled corticosteroids (ICS). Comparison between FEV1\% pred at baseline and follow-up visit showed significant improvement only in subjects with lower eosinophilia (91.9{\textpm}17.5 vs 96.6{\textpm}15.7, p=0.01). Logistic regression analysis (mean annual change in FEV1 \< than median value -32.9 ml/yrs as dependent variable) was performed.View this table:Conclusion: Baseline FEV1 and sputum eosinophilia are both determinants of a more rapid FEV1 decline in patients with OA still exposed in the workplace.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p4942}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }