RT Journal Article
SR Electronic
T1 Impaired lung function in children born preterm is related to severity of neonatal lung disease
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2012
VO 38
IS Suppl 55
A1 Karla M. Logie
A1 James T.D. Gibbons
A1 Shannon J. Simpson
A1 Andrew C. Wilson
A1 J. Jane Pillow
A1 Graham L. Hall
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2012.abstract
AB Advances in neonatal care have led to a shift in the pathophysiology of bronchopulmonary dysplasia (BPD). The impact of contemporaneous preterm birth and BPD on long term respiratory health remains unclear. This study aims to relate mid-childhood respiratory function with neonatal variables in children born ≤32 w gestational age (GA).Methods: Children aged 9 to 11 y (≥ 37 w GA controls, n=37; 84 born ≤32 w gestation including 53 with BPD) performed 4 lung function tests (forced oscillation, static lung volumes, spirometry and gas transfer (DLCO)). Associations between lung function (expressed as Z scores) and neonatal variables (GA, birth weight Z-score and durations of mechanical ventilation (MV) and O2) were explored using multiple linear regression.Results: Children with BPD had increased respiratory resistance (Rrs) and reactance (Xrs), reduced FEV1 and FEF25-75 compared to children born preterm without BPD and controls (one-way ANOVA; post-hoc comparisons p<0.04). DLCO was reduced in the BPD group compared to preterm but not healthy children (p<0.05). Static lung volumes were not different between groups. Duration of supplemental O2 was associated with increased Rrs (p<0.005) and reduced DLCO (p=0.01). Duration of MV was associated with increased Xrs (p=0.001) and together with birth weight Z-score (p=0.02), was predictive of reduced FEV1 (p=0.005).Conclusions: Children born ≤32w GA with BPD have worse lung function compared to preterm children without BPD. Impaired lung function in mid-childhood is associated with severity of neonatal lung disease as reflected by duration of MV and supplemental O2, further reinforcing the long–term impacts of preterm birth on lung health.