@article {Logiep2012, author = {Karla M. Logie and James T.D. Gibbons and Shannon J. Simpson and Andrew C. Wilson and J. Jane Pillow and Graham L. Hall}, title = {Impaired lung function in children born preterm is related to severity of neonatal lung disease}, volume = {38}, number = {Suppl 55}, elocation-id = {p2012}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Advances in neonatal care have led to a shift in the pathophysiology of bronchopulmonary dysplasia (BPD). The impact of contemporaneous preterm birth and BPD on long term respiratory health remains unclear. This study aims to relate mid-childhood respiratory function with neonatal variables in children born <=32 w gestational age (GA).Methods: Children aged 9 to 11 y (>= 37 w GA controls, n=37; 84 born <=32 w gestation including 53 with BPD) performed 4 lung function tests (forced oscillation, static lung volumes, spirometry and gas transfer (DLCO)). Associations between lung function (expressed as Z scores) and neonatal variables (GA, birth weight Z-score and durations of mechanical ventilation (MV) and O2) were explored using multiple linear regression.Results: Children with BPD had increased respiratory resistance (Rrs) and reactance (Xrs), reduced FEV1 and FEF25-75 compared to children born preterm without BPD and controls (one-way ANOVA; post-hoc comparisons p\<0.04). DLCO was reduced in the BPD group compared to preterm but not healthy children (p\<0.05). Static lung volumes were not different between groups. Duration of supplemental O2 was associated with increased Rrs (p\<0.005) and reduced DLCO (p=0.01). Duration of MV was associated with increased Xrs (p=0.001) and together with birth weight Z-score (p=0.02), was predictive of reduced FEV1 (p=0.005).Conclusions: Children born <=32w GA with BPD have worse lung function compared to preterm children without BPD. Impaired lung function in mid-childhood is associated with severity of neonatal lung disease as reflected by duration of MV and supplemental O2, further reinforcing the long{\textendash}term impacts of preterm birth on lung health.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p2012}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }