RT Journal Article SR Electronic T1 Prostate biopsy for diagnostic of prostate tuberculosis JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p2692 VO 38 IS Suppl 55 A1 Denis Kholtobin A1 Ekaterina Kulchavenya A1 Elena Brizhatyuk YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p2692.abstract AB World Health Organization (WHO) recognized tuberculosis (TB) as a global problem, but meant TB as a whole, mostly pulmonary TB, although 77% men died from TB, had prostate TB, mostly overlooked alive. Prostate TB has an importance due to: 1. It is a sexually transmitted disease; 2. It leads to infertility; 3. It results in chronic pelvic pain, that significantly reduces a quality of life; 4. It decreased a sexual function, that reduces a quality of life again.The aim of our study was to estimate a role of a prostate biopsy in early diagnosis of a prostate TB.93 patients suspicious on prostate TB were enrolled in study. All underwent ultrasound guided core prostate biopsy (Middle size needle 18 g, 19 mm length) with local anaesthesia. Straws were investigated by PCR, pathomorphology and culture.Results: Common complaints were pain (96.8%), dysuria (79.6%); laboratory findings - leucospermia (73.1%), haemospermia (51.6%). 37.6% had TB history, 34.4% had active TB of another localization, mostly – pulmonary. Results of PCR: HPV – 10.7%, Ureaplasma – 2.2%. Mycobacteria culture was positive in 6.9%. Pathomorphologically in 94.6% inflammation was found, in 65.6% – fibrosis, in 9.7% - intraprostatic neoplasia, in 5.4% - cancer, in 24.7% - TB.Conclusion: The diagnosis of prostate TB is a very difficult task, because clinical features and laboratory signs are non-specific. Pathognomonic symptom is a cavern, but caverns mean late-diagnosed complicated form, cavernous prostate TB can't be cured neither chemotherapy nor by surgery. Prostate TB in early infiltrative non-cavernous stage may be diagnosed by PCR, culture or pathomorphology. Possibility of these methods alone is poor, it is necessary to use its in combination.