PT  - JOURNAL ARTICLE
AU  - Yong Lin
AU  - Qiang Zhang
AU  - Xue-Feng Ling
AU  - Si-Qing Sun
TI  - Detection of serum anti-endothelial cell antibodies (AECA) in COPD rats
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p3891
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p3891.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p3891.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: Chronic obstructive pulmonary disease (COPD) may be a systemic disease of autoimmune abnormality. Alveoli disorganization in COPD includes micro-vascular destruction. Anti-endothelial cell antibodies (AECA) are a type of circulating antibodies which bind to endothelial antigens and induce endothelial cell damage. It is unclear whether the AECA play a role in COPD mechanisms.Objective: To detect the serum level of anti-endothelial cell antibody in adult rats of COPD in order to investigate the significance of AECA in COPD mechanism.Methods: Replicated COPD rat models with passive-smoking and lipopolysaccharide trachea injections. The expression of AECA was examined by ELIZA.Results: In smoking rats with simple airway inflammation, the alveolar septum thickened but was not destroyed, AECA149.48±7.47 ng/L. COPD rats had airway inflammation and emphysema, AECA138.46±7.85 ng/L. Compared with the normal control group (62.89±10.68 ng/L), AECA levels in the two test groups were much higher.Conclusion: Autoimmunity constituents which induce endothelial cell lesions may participate in the pathogenesis of COPD; detection of serum AECA levels in COPD may have some clinical significance.