PT  - JOURNAL ARTICLE
AU  - Olena Oliveira
AU  - Miguel Villar
AU  - Raquel Duarte
TI  - Predictors of treatment outcome in multidrug-resistant tuberculosis
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p3296
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p3296.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p3296.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Multidrug-resistant tuberculosis (MDR-TB) is a challenge to control programs.In these cases, treatment is more complex, more expensive and very often less successful.The purpose of this study was to analyze the factors that could influence (positively or negatively)the outcome.To examine this issue we used data from the National Tuberculosis Program in Portugal SVIG-TB.For the study,we included all MDR-TB cases reported from January 2000 to December 2008. To identify the predictive factors related to the outcome of treatment we used univariate and multiple logistic regression models with the clinical variables.During the studied period 130 patients with MDR-TB were notified, of these 94 (72,3%) were male and 36 (27,7%) female, mean age 42 years old (range 40-44). Forty-six patients (35,5%) had a previous treatment and 39 (30%) were HIV positive. Treatment success (cured or completed treatment) was observed in 80 (61,5%) patients. Susceptibility and use of pyrazinamide or ethambutol, susceptibility and use of a fluoroquinolone, the use of five or more drugs in the treatmant regimen, sputum culture conversion after 2 months of treatment were predictors of successful outcome of treatment. Treatment insucess (death, default and failure) was observed in 47 (36,1%) patients. Previous treatment, HIV co-infection, presence of cavitation on the chest radiograph, resistance of two more drugs than just isoniazid and rifampicin and positive cultures after 2 to 3 month of treatment were predictors of poor treatment outcome.Rapid diagnosis of drug resistance and an appropriate therapy for effective treatment are important conditions for the prevention of spread of resistant strains and control of MDR-TB.