RT Journal Article
SR Electronic
T1 Metabolic and inflammatory profile in obese and non obese children with obstructive breathing disorders
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2232
VO 38
IS Suppl 55
A1 Silke Weber
A1 Έrico Moreira
A1 Renata Mizusaki Iyomasa
A1 Ana Carolina Silveira
A1 Cilmery Kurokawa
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2232.abstract
AB Introduction: Adult OSA is a known risk factor for metabolic diseases, but still unexplored in children. Obesity, an important cofactor, is increasing in the pediatric population.Aim: To study the metabolic profile and the levels of TNF-α in in obese and non obese children with obstructive breathing disorders.Methods: Children of both genders, aged 6 to12 years, with obstructive breathing disorders were included. Children were divided in 2 groups, non obese and obese (Z score > +2). diorespirarory sleep study. In the morning after the sleep study, blood samples were taken for analysis. The lipids, glucose, insulin, tyroxin and TNF-α levels were determined. Results were compared for the 2 groups.Results: 17 children, median age of 6.5 years, 10 obese- and 7 non obese, were included. There glucose level was 85 mg/dL in both groups. Insulin level was higher in the obese group (10,7±2,36 mU/L X 6,7±3,29 mU/L, p<0.01). There were no difference in total cholesterol (168,4±37 mg/dL X 181,5±33, p>0.05), HDL (56,8±14,5 mg/dL X 49,5±17,8 mg/dL,p>0.05) and LDL (98,6±27,7 mg/dL X 110,7±28 mg/dL) in the non obese and obese group, respectively. TGL levels were higher in the obese group (106,5±37 mg/dL X 64,3±23 mg/dL).Thyroxin and TSH levels did not differ in both groups. The average TNF-α was 0,36±0,09 pg/ml, but differed in obese 0,56±0,53 pg/ml and 0.10±0,07 pg/ml (p<0.05).Conclusion: Obesity may cause additional metabolic changes (increased insulin resistance and TGL levels) in children with obstructive breathing disorders. The metabolic inflammatory profile must be investigated for a better understanding of OBD in childhood.