TY - JOUR T1 - Bronchial antiproteases activation as a tolerance factor to COPD development in healthy long term smokers JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3898 AU - Sergey Fedosenko AU - Georgiy Chernogoryuk Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3898.abstract N2 - Not all smokers suffer from COPD. It is possible that tolerance to COPD emergence among healthy long term smokers is supported by supressing the excessive proteolytic activity.Aim: To investigate the factors of tolerance to COPD development among healthy long term smokers according to content of proteases and antiproteases in induced sputum.Methods: There are 145 stable COPD pftients and 48 long term smoking men (>30 pack/year), without symptoms of COPD have been enrolled in our research. The control group consisted of 48 healthy nonsmokers volunteers. All patients were men of identical age of 59.2±4.07 years. Induced sputum was studied on elastase, protease's inhibitor α1, macroglobulin α2.Results: An activity of protease's inhibitor α1 and macroglobulin α2 in induced sputum of long term smokers is higher than among healthy non-smokers and patients with COPD.View this table:The activity of proteases and antiproteases in induced sputumConclusion: The tolerance to development COPD among long term smokers is supported high activity of antiproteases in bronchial region. ER -