PT - JOURNAL ARTICLE AU - Sona Franova AU - Marta Joskova AU - Martina Sutovska AU - Olga Pechanova AU - Gabriela Nosalova TI - Polyphenolic compounds and experimentally induced allergic asthma DP - 2011 Sep 01 TA - European Respiratory Journal PG - p4099 VI - 38 IP - Suppl 55 4099 - http://erj.ersjournals.com/content/38/Suppl_55/p4099.short 4100 - http://erj.ersjournals.com/content/38/Suppl_55/p4099.full SO - Eur Respir J2011 Sep 01; 38 AB - Some epidemiological studies related asthma symptoms contain data supporting the idea that health benefits associated with fruits, vegetables and red wine in the diet are probably linked with polyphenols that most likely reduce the occurrence of asthma complications.Our experimental work was aimed at influence of polyphenols on airway hyperreactivity and allergic inflammation in experimental conditions of allergic asthma (21 days OVA sensibilization) after their short- or long-term (21 days) administration. We compared the activities of polyphenolic compounds mixtures from red wine (Provinol) and red fruits (Flavin7) and polyphenolic substances - resveratrol and quercetin.The changes in reactivity of respiratory system after polyphenols administration we measured: by in vitro method; by in vivo method (used whole-bodyplethysmograph).The degree of inflammation was evaluated by eosinophil calculation and by estimation of inflammatory cytokines IL-4, IL-5 in bronchoalveolar lavage fluid (BALF).The results of our experiments showed that: Polyphenolic compounds Provinol and Flavin7 posses an efficient antiasthmatic activities. They cause bronchodilation and also suppress asthmatic inflammation in the airways. Quercetin and resveratrol are able to induce only acute bronchodilation without antiinflammatory effects.Our results demonstrate positive antiasthmatic effect of mixture of polyphenols. This outcome confirm the hypothesis, that may become an additional therapy in prevention of airway hyperresponsiveness in asthma subjects.