RT Journal Article SR Electronic T1 Predictors of asthma symptom remission after five years of age JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p1499 VO 38 IS Suppl 55 A1 Steve Turner A1 Nanda Prabhu A1 Rebecca Cutts A1 Keith Allen A1 Peter Helms A1 Anthony Seaton A1 Graham Devereux YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p1499.abstract AB Introduction: Childhood asthma is a common condition characterised by relapse and remission. Here we sought to identify the precision of physiological measurements made in 5-year-olds for predicting asthma outcome at 10 years of age.Methods: As part of a cohort study, 5 year old children attended a clinical assessment which included skin prick reactivity, spirometry and bronchodilator response. A respiratory symptom questionnaire was completed at ages 5 and 10 years. Children were categorised as having persistent asthma, early remittent asthma, later onset asthma or being non-asthmatic.Results: Of the 1924 originally recruited, questionnaire data were available in 808 children at both 5 and 10 years of age including 37 with persistent asthma, 30 with early remittent asthma and 33 with later onset asthma. Skin prick reactivity was determined in 483 5-year-olds, spirometry in 410, bronchodilator response (BDR) in 164 and FENO in 110. Atopy had sensitivity of 82% [95% CI 68, 92] and specificity of 57% [95% CI 42, 68] for predicting persistent asthma in symptomatic 5–year-olds and a sensitivity of 72% [95% CI 50, 87%] and specificity of 79% [95% CI 78-80] for predicting later onset asthma in asymptomatic 5-year-olds. Regardless of asthma status at 5 years, FENO >10.7ppb had a sensitivity of 62% and specificity of 89% for asthma at 10 years. Spirometry and BDR were not predictive of later asthma outcomesConclusions: In this community-based cohort, objective physiological measurements taken in 5-year-olds were able to predict asthma outcome in later childhood. The absence of atopy or elevated FENO in a young child with asthma or asthma-like symptoms may be helpful in predicting low risk for future asthma symptoms.