TY - JOUR T1 - Late-breaking abstract: Relationship with hemoglobin A1c and exacerbations of COPD. A preliminary study JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - 3413 AU - Haruka Aoki AU - Takeshi Hisada AU - Hiroaki Tsurumaki AU - Reiko Yoshino AU - Hidemasa Kuwabara AU - Tamotsu Ishizuka AU - Kunio Dobashi AU - Masatomo Mori Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/3413.abstract N2 - Background and objective: Hyperglycaemia during hospital admission is associated with poor outcomes in patients admitted with acute myocardial infarction, stroke and pneumonia. Systemic inflammation may represent a possible cause of glycometabolic disorder. We studied that assocition Hemoglobin A1c with an increased risk of acute exacerbation of COPD (AECOPD).Methods: Patients with COPD were prospectively enrolled and followed between 2010 and 2011. Medical records, HbA1c, fasting glucose and metabolic markers were assessed in 29 patients.Results: A total of 29 patients (mean age of 78.2 years) were recruited, 11 with AECOPD and 18 without. Clinical data were collected from the patients. HbA1c levels of AECOPD patients were significantly higher on entry point compared with other patients (5.783±0.2638; 4.983±0.1778, respectively p=0.0361). Moreover, there was a trend for increased length of stay and frequency of admissions in patients with higher levels of HbA1c. (4.5%<HbA1c≤5%; 5%<HbA1c≤5.5%; 5.5%<HbA1c≤6%; HbA1c>6%, 15days (0.9/year (y)); 26days (1/y); 23days (1.3/y); 30days (2.3/y), respectively)Conclusion: Previous study revealed that comorbid diabetes prolongs length of stay and increases risk of death in patients with AECOPD. However, less evidence exists for relationship of HbA1c with AECOPD. For the first time our study demonstrates that HbA1c is a prognostic factor associated with AECOPD. Taken together with a previous study that revealed a similar trend, our study suggests that further studies are now required to elucidate the reasons for these poorer outcomes, in particular whether premorbid glycaemic control or inpatient control is responsible, as these are potentially modifiable factors. ER -