TY - JOUR T1 - Static lung volumes in lung transplant recipients with bronchiolitis obliterans syndrome JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p1203 AU - Therese Small AU - Christopher Ward AU - James Lordan AU - Andrew Fisher AU - Paul Corris AU - John Gibson Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p1203.abstract N2 - The bronchiolitis obliterans syndrome (BOS), post lung transplantation, is defined and monitored by FEV1. Progressive pulmonary hyperinflation may accompany airway obstruction in BOS and assessing hyperinflation might give a more sensitive signal. However, after single lung transplantation (SLT), for chronic airway disease, the native hyperinflated native lung might compromise interpretation of lung volume measurements. We therefore compared plethysmographic lung volumes, including inspiratory capacity (IC), at the time of diagnosis of BOS in 2 groups of patients: post SLT and post sequential single lung transplantation (SSLT).We studied 32 patients: 11 SLT (9 COPD; 2 OB) and 21 SSLT (6 COPD; 1 OB; 14 cystic fibrosis). The SSLT group were significantly younger (median 38 v. 54 years).View this table:The SLT group had larger TLC and FRC, while IC was similar in the two groups and, as a proportion of VC, was actually greater in the SLT group.IC was relatively well preserved in the SLT patients with early BOS, despite the presence of a hyperinflated native lung. Longitudinal lung volume measurements might usefully evaluate the progress of BOS in both SLT and SSLT recipients. ER -