@article {Leep2795, author = {Yao-Ling Lee and Wer-Erh Cheng and Shuo-Chueh Chen and Chuen-Ming Shih and Wei Chen}, title = {Association of genetic polymorphisms of matrix metalloproteinase (MMP)14 to the susceptibility of non-small cell lung cancer}, volume = {38}, number = {Suppl 55}, elocation-id = {p2795}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Background: Matrix metalloproteinase (MMP)14 is a cell surface proteinase that displays a broad spectrum of activity against extracellular matrix components and promotes the invasion/metastasis of cells. MMP14 is overexpressed in NSCLC, and the level is correlated with poor survival. We investigate the MMP14-165, +7096 and +8153 genetic polymorphisms for their role in the susceptibility to NSCLC.Methods: Through a case-control study design, genomic DNA samples isolated from peripheral lymphocytes of 267 NSCLC patients and 328 controls, who were age and sex-matched and recruited from the health check-up unit, were subjected to polymorphism analysis with PCR-RFLP technique.Results: The distribution of the genotype frequencies of MMP14 -165 (G/T), MMP14 +7096 (T/C) and MMP14 +8153 (G/A) were significantly different between the lung cancer patients and the healthy controls. Logistic regression analysis revealed that higher odds ratios (ORs) for lung cancer were seen for individuals with MMP14 -165 T/T genotype against GG/GT genotypes (an OR of 1.84, 95\% CI 1.22-2.77, p=0.005), MMP14 +7096 CC genotype against TT/TC genotypes (an OR of 1.79, 95\% CI 1.19-2.70, p=0.005), and MMP14 +8153 GA genotype against GG genotypes (an OR of 2.07, 95\% CI 1.36-3.14, p=0.001).Conclusions: A significant association between the polymorphisms of MMP14 gene and the susceptibility to NSCLC was demonstrated.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/p2795}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }