RT Journal Article SR Electronic T1 Physical, social, and psychological function in asthma patients with and without analgesic tolerance JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP p1298 VO 38 IS Suppl 55 A1 Deniz Inal-Ince A1 Sema Savci A1 Naciye Vardar-Yagli A1 Ebru Calik A1 Melda Saglam A1 Hulya Arikan A1 Meral Bosnak-Guclu A1 Gul Karakaya A1 Fuat Kalyoncu YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/p1298.abstract AB Purpose: Ingestion of aspirin and similar drugs triggers severe bronchospasm in some asthmatic patients. The purpose of this study was to compare physical, social and psychological function between analgesic intolerant and tolerant asthmatic (AIA and ATA, respectively) patients.Methods: Twenty-seven AIA and 29 ATA patients participated in this study. Respiratory and quadriceps muscle strength (QMS) were measured. Asthma Control Questionnaire and Asthma Knowledge Test were applied. Six-minute walk test was performed, and physical activity level was determined using International Physical Activity Questionnaire (IPAQ). Dyspnea and fatigue perception was evaluated using modified Medical Research Council dyspnea scale and Fatigue Severity Scale, respectively. Psychological function was evaluated using Beck Depression Inventory and State Trait Anxiety Inventory. General and disease specific quality of life were determined using Nottingham Health Profile and Asthma Quality of Life Questionnaire, respectively.Results: The FEV1, QMS, IPAQ walking score, and Asthma Knowledge Test score were significantly higher in AIA patients as compared to those of ATA patients (p<0.05). No significant differences were found in asthma control, respiratory muscle strength, symptom perception, six-minute walk test distance, psychological function, and quality of life between the two groups (p>0.05).Conclusion: The AIA patients share similar characteristics with ATA patients except better airway function, peripheral muscle strength and physical activity level, and worse asthma knowledge. Presence of analgesic intolerance effects components of physical function in asthma.