TY - JOUR T1 - Effect of benzylpenicillin-ciprofloxacin vs. ceftriaxon-ciprofloxacin in treatment of massive pneumonia (CAP-community acquired pneumonia) JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2568 AU - Vojislav Radosavljevic AU - Milica Obradovic AU - Natasa Petrovic Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2568.abstract N2 - In the past few years a high level of massive pneumonia has been noticed. The aim of study was to compare the effect of benzylpenicilln-ciprofloxacin versus ceftriaxon-ciprofloxacin in treatment of massive pneumonia.Material and methods: There were 60 patients (male-34;female-26;22-68 years old) who were divided in two groups according to the therapeutical treatment. All patients had radiological image of lobar massive CAP with biochemistry verification, and port score between 70-90. The first group with thirty patients was treated with a combination of benzylpenicillin (1.6 million i.m. per day)-ciprofloxacin (500mgx2 p.o. per day) for seven days. The second group with also thirty patients was treated with a combination of ceftriaxon (2g per day)-ciprofloxacin (500mgx2) also for seven days. After the treatment we compared radiological image according to RECIST criteria.Results: In the first group were 14 with complete, 10 with partial, 2 with stable response and 4 with progression of disease. In the second group there were 16 with complete, 7 with partial, 4 with stable response and 3 with progression of disease. There were no deaths and no complications during the treatment. There was no statistical significance between the two groups of patients in treatment of massive pneumonia (CAP-Community acquired pneumonia) p>0.05.Conclusion: According to our result we can conclude that the combination of benzilpenicilin-ciprofloxacin has given good results in treatment of massive lobar pneumonia (CAP) with good safety and tolerance. Costs benefit recommends benzylpenicillin-ciprofloxacin for therapy of choice. ER -