TY - JOUR T1 - Features of lung damage in adult patients with severe influenza A (H1N1) JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - 2986 AU - Olga Titova AU - Dmitry Larin AU - Vladimir Volchkov Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/2986.abstract N2 - Methods: 445 adult patients (36,5±13,5 years) were hospitalized with a suspected influenza A (H1N1) from October 2009 to January 2010. In 84% of cases diagnosis was confirmed by RT-PCR test. Clinical, laboratory, and X-ray examinations, complex study of respiratory function were carried out.Given the threat of influenza pandemic in 2011 the aim was the study of detection frequency, risk factors for lung damage, and features of convalescence period in patients with severe influenza A (H1N1).Results: The average score on Charlson index was 1,55±0,90. In 181 patients pneumonia was diagnosed, double pneumonia - in 23% of cases. Acute respiratory distress syndrome developed in 12 patients and they needed in ventilation support. Four patients died within 20 days (IQR of 10-25). The relative risk of death was associated with higher estimates for Charlson index (RR 1,38; 95% CI 1,04 to 1,82, p=0,02) and APACHE II scale (RR 1,242; 95% CI 1,284 to 1.602, p=0,005). In convalescents the increased lung pattern on radiographs (39%), decreased lung diffusion capacity (45%), restrictive changes (15%) were the most frequent and long-lasting changes. 28% of patients having these changes applied for medical care within 6 months after being discharged.Conclusion: The high score on Charlson index and APACHE II scale are risk factors for development of severe pneumonia in presence of influenza A (H1N1). Changes of ventilation functional tests associated with persistent disorders of pulmonary circulation remain for long time in 45% of patients undergoing pneumonia. This group of patients is of particular interest and requires further observation. ER -