TY - JOUR T1 - Role of endothelial dysfunction, disturbance of haemostatic reactions in pathogenesis of acute exacerbation of chronic obstructive pulmonary disease (AE COPD) JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p3024 AU - I.Ya. Tseimakh AU - A.P. Momot AU - G.I. Kostjuchenko AU - T.A. Kornilova AU - I.P. Kramar AU - J.A. Filonova AU - A.G. Chuchalin Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p3024.abstract N2 - Purpose: It is to research interrelations of endothelial dysfunction, system inflammatory and haemostatic reactions at patients with AE COPD.Materials and methods: In open prospective clinical investigation 111 patients with 2 or 3 positive criteria Anthonisen et al. (1987) were included. Men were 91 people (82%), women - 20 people (18%). The smoking index was 37,5±2,06 pack-years. Patients with AE COPD divided on two subgroups: 1st - patients without bronchoectasia, 2nd - patients with bronchoectasia. All patients received therapy by system glucocorticoids. The control group included 35 healthy non-smoking people with middle age 25,9±1,36 years, from them 27 (77,1%) men and 8 (22,9%) women. It was accomplished immuneenzyme definition of CRP, endotelin-1, D-dimers and homocystein maintenance in blood before treatment.Results: Direct correlation communication between indexes CRP and endotelin-1 (r=0,80, p<0,001), indexes CRP and D-dimers (r=0,65, p<0,01) in the AE COPD was observed. Dynamics of indexes of endothelial dysfunction and thrombogenic risk at patients with various phenotypes AE COPD are in table 1.View this table:Table 1Conclusion: At patients with AE COPD it is increased levels of D-dimers, which indicates that specifies on thrombogenic and thromboembolic risks. ER -