@article {Norb{\"a}ck1727, author = {Dan Norb{\"a}ck and Nina Fabjan and Guihong Cai and Ivan Kreft and Erik Lampa and Gunilla Wieslander}, title = {Cat, dog and horse allergens in day care centres in Uppsala, Sweden, associations with FeNO and dyspnea}, volume = {38}, number = {Suppl 55}, elocation-id = {1727}, year = {2011}, publisher = {European Respiratory Society}, abstract = {Aim: To study associations between FeNO, FEV1 and dyspnoea in day care centre staff and levels of cat, dog and horse allergens in day care centres.Methods: 62 staff in 5 day care centres in Uppsala participated in a study performed 3 times in each subject in spring, in connection with a diet study. Dust was collected by vacuum cleaning and analysed for cat (Fel d1), dog (Can f1) and horse (Equ cx) allergens by ELISA. Amount of allergens per ALK-filter was calculated by multiplying concentration with amount of fine dust. Airborne allergens were sampled in Petri dishes for 1 week. Exhaled NO was measured by NIOX MINO and FEV1 by dynamic spirometry. Dyspnoea was rated from 0-100\%. FeNO and dyspnoea were log-transformed and associations analysed by multiple linear regression, adjusting for age, atopy, smoking, and body mass index (BMI). All were females.Results: There were no pets in any building, but all allergens were common. Geometric mean (GM) (ng/g) were 1199 Fel d1, 666 Can f1 and 478 Equ cx. Fel d1 was found in 100\% (GM=29.8 ng/m2 and day), Can f 1 in 33\% and Ecu c x in 13\% of Petri dish samples. FeNO was higher at higher amount of Fel d1 (p=0.04) and Can f1 (p=0.04) and lower at higher amount of Equ cx (p=0.01). No associations were found for FEV1 or dyspnoea and allergen levels.Conclusion: Cat, dog and horse allergens were common in the day care centres, due to track in by clothes or hair. Cat and dog allergens in day care centres can be a risk factor for airway inflammation, measured as FeNO. The negative association for horse allergen remain unclear. It could be due to co-variance with some protective indoor factor, or a healthy life style related to horse riding.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/38/Suppl_55/1727}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }