PT  - JOURNAL ARTICLE
AU  - Joan B. Soriano
AU  - Marc Miravitlles
AU  - Francisco Garcia-Rio
AU  - Luis Muñoz
AU  - Guadalupe Sanchez
AU  - Victor Sobradillo
AU  - Enric Duran
AU  - Dolores Guerrero
AU  - Julio Ancochea
TI  - Distribution and determinants of restrictive functional pattern
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p2127
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p2127.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p2127.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - A restrictive functional pattern is a common finding when performing spirometry, even in the absence of signs of pulmonary fibrosis or other diagnoses. This EPI-SCAN sub-analysis (a population-based, cross-sectional study in eleven participating centres in Spain) aims to determine the frequency, geographic variation, individual consequences (respiratory symptoms, impact on activities of daily living, and quality of life), and “severity” of the restrictive functional pattern defined according to pre-BD spirometry as FEV1/FVC ≥ 0.70 and a predicted FVC <80% as per current ATS/ERS guidance. The prevalence of restrictive functional pattern was 12.7% (95% CI 9.7-15.7), with maximum in Seville (19.4%) and Burgos (18.5%) and minimum in Oviedo (5.2%) and Madrid-La Princesa (5.7%), p <0.05. Although the vast majority (97.1%) of participants with a restrictive functional pattern are objectively considered “mild” by spirometry (%predicted FVC 50-80%), they reported more phlegm, dyspnea, and wheezing than healthy, control participants, and in all SGRQ domains of quality of life and LCADL activities of daily living they scored worse (p <0.05); actually, they scored similarly to participants with COPD in both (p n.s.). In a multivariate analysis, only older age, male gender, lower education, and body mass index (BMI) ≥ 30.0 kg/m2 were independently associated with having a restrictive functional pattern. We conclude that a restrictive functional pattern in spirometry is a common finding (12.7%), and with highly variable geographical distribution (range 3.7), whose population burden is important in terms of quality of life and activities of daily living and similar to that of an obstructive pattern compatible with COPD.