RT Journal Article SR Electronic T1 Early life exposure to locally-generated PM10 and lung function measurements at school-age JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 3406 VO 38 IS Suppl 55 A1 Marie-Pierre F. Strippoli A1 Anna Hallberg A1 Caroline S. Beardsmore A1 Michael Silverman A1 Jonathan Grigg A1 Claudia E. Kuehni YR 2011 UL http://erj.ersjournals.com/content/38/Suppl_55/3406.abstract AB Aim: Although multiple studies have linked short-term exposure to particulate matter (PM10) with respiratory symptoms and lung function (LF) in children, little is known about effects of early lifetime exposure.Methods: In a population-based cohort study (n=4400) we collected information on residential history from birth to early school-age (6-9 yrs) and modelled primary PM10 exposure throughout childhood using Airviro. We assessed wheeze symptoms by parental questionnaires and performed spirometry in a sample of children aged 9-13 yrs (n=399). We analysed association between early life exposure to PM10 and LF using linear regressions controlling for a number of confounders and attacks of wheeze at school-age.Results: Median (interquartile range) of early life exposure to PM10 was 1.83 (0.93-2.70) μg/m3. Mean (SD) FVC, FEV1 and MEF50 were 2.42 (0.44) l, 2.11 (0.39) l and 2.82 (0.73) l/s respectively. After adjustment FVC was lower with higher exposures to PM10.We found no significant association with FEV1 or MEF50. When adjusting for number of attacks results were similar.Conclusions: Lifetime exposure to primary PM10 was associated with lower FVC at school-age which might be independent of wheezing disorders. This result is compatible with a chronic effect of air pollution on normal lung function growth, resulting in a restrictive rather than an obstructive pattern.Funding: SNF 3200B0-122341, Asthma UK 07/048