RT Journal Article
SR Electronic
T1 Agreement between interrupter resistance and spirometry in a large population of asthmatic children
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p2019
VO 38
IS Suppl 55
A1 Nicole Beydon
A1 Bruno Mahut
A1 Maingot Lucia
A1 Houda Guillo
A1 Marie-Claude La Rocca
A1 Noria Medjahdi
A1 Marc Koskas
A1 Michèle Boulé
A1 Christophe Delclaux
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p2019.abstract
AB Background: Interrupter resistance (Rint) is routinely used to assess airway patency in children, but its relationship with spirometry has never been assessed in a large population of children.Objectives: A retrospective study to compare baseline values and post-bronchodilator (post-BD) changes in Rint and spirometry in asthmatic children.Methods: Rint measures (SpiroDyn'R, Dyn'R, France) were performed before spirometry (Masterscreen, Jaeger, Germany). Statistics: correlations between baseline Rint and FEV1 or FEF2575%, and ROC study for the Rint cutoff to distinguish between children with and without reversibility in FEV1 (>12% baseline).Results: Data from 645 children (408 boys, median (range) age 7.9 (4.2-18.3) y) showed significant correlations between Rint and FEV1 or FEF2575% (r=0.69 and 0.71, respectively for raw data, and r=0.49 and 0.54, respectively for% of predicted; all p<0.0001).Figure 1Figure 2Reversibility in FEV1 (270 children) was best detected by a -35% of predicted Rint decrease (AUC=0.79, 0.70 sensitivity and specificity).Conclusion: We found a good agreement between Rint and spirometry to assess airway caliber and study BDeffect.