RT Journal Article
SR Electronic
T1 Periodic breathing and oxygenation pattern depending on severity of bronchopulmonary dysplasia
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP p3458
VO 38
IS Suppl 55
A1 Natalja Petrova
A1 Irina Dobrodeeva
A1 Yuri Petrenko
A1 Nikolai Shabalov
A1 Vyacheslav Lubimenko
YR 2011
UL http://erj.ersjournals.com/content/38/Suppl_55/p3458.abstract
AB Objective: Periodic breathing (PB) is a common breathing pattern in premature infants. Our aim was to study PB occurrence and its impact in oxygenation in infants with moderate to severe and mild bronchopulmonary dysplasia (BPD) compared to infants without BPD.Methods: We performed pneumography on 25 premature infants with BPD (1 case of severe, 8 of moderate, and 16 of mild BPD) and 25 non-BPD prematures comparable in gestation age (26-30 weeks). Infants were examined 1–3 times at ages of less then 29 days, 29-50 days, more than 50 days. Incidence of main neurologic abnormalities appeared not to differ among groups.Results: Occurrence and duration of PB did not differ in infants with mild BPD and without BPD at all ages. Infants with moderate to severe BPD demonstrated no PB during first 28 days, lesser incidence of PB at 29-50 days (1 of 3 infants), lesser duration of PB at 50 days and older (4,3±3,1% of recording length) compared to infants with mild BPD (8 of 10 infants; 18,3±6,7%, respectively; P<0,05) and without BPD (17 of 18 infants; 13,3±5,3, respectively; P<0,05). In most cases PB was accompanied by arterial O2 saturation (SpO2) oscillation. The minimal SpO2 values during this oscillation were >80% in all except one cases of PB in infants without BPD. In BPD group in 5 of 9 PB cases at 29-50 days and 5 of 15 PB cases at 50 days and older SpO2 was 80% and lower; these were infants with both moderate to severe and mild BPD.Conclusion: Infants with mild BPD seem to have more active peripheral chemoreceptors compared to prematures with moderate to severe lung disease. PB may be associated with significant desaturations in infants with BPD regardless of its severity.