TY - JOUR T1 - Peculiarities of peripheral blood flow reaction during cold air bronchoprovocation JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p1531 AU - Juliy M. Perelman AU - Anna G. Prikhodko Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p1531.abstract N2 - Background: Peripheral vessels reaction to different stimuli may be a sign of systemic vascular disturbances in chronic pulmonary diseases. It is unknown if cold airway hyperresponsiveness (CAHR) accompanied by any changes in systemic peripheral circulation.Aim: To study peculiarities of peripheral vasomotor reaction during local airway cooling.Methods: The reaction of peripheral vessels of finger (àà. digitales palmares propriae) during and after 3-min isocapnic cold (-20°C) air hyperventilation was studied in 11 healthy persons and 31 patients with chronic pulmonary diseases (bronchial asthma and chronic bronchitis) having CAHR. The amplitude of pulse wave (APW) was evaluated by photoplethysmography of finger.Results: A phase reaction of finger artery to cold air inhalation was revealed in healthy persons. By the end of the 3rd min of hyperventilation there was a progressive drop of APW (-30.2±8.7%) as a result of vasoconstriction with further short-term vasodilation proved by the growth of APW higher than the initial level (8.7±6.5%) immediately after provocation cessation and its additional fall on the 5th min of recovery (-15.5±7.3%), which meant a repeated vessel spasm. In group of patients cold air inhalation led to sustained APW drop both during provocation (-21.4±8.9%) and recovery period (1st and 5th min) -26.2±7.6% (p<0.01); -10.5±7.8%, respectively. There was a correlation among airway reaction, changes in peripheral blood flow, skin temperature at the beginning and at the end of the bronchoprovocation in patients.Conclusions: Revealed abnormalities in peripheral microcirculation in patients with the changed airway responsiveness can be an early sign of systemic vascular dysfunction. ER -