PT  - JOURNAL ARTICLE
AU  - Sergio Romero-Diaz
AU  - Rafael J. Hernandez-Zenteno
AU  - Fernando Flores Trujillo
AU  - Amaya Amaya Bermudez
AU  - Carlos Espinosa de los Monteros
AU  - Raul H. Sanores
AU  - Alejandra Velazquez Montero
AU  - Luis Torre Bouscoulet
AU  - Alejandra Ramirez-Venegas
TI  - Early clinical abnormalities after H1N1 influenza pneumonia
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p4344
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p4344.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p4344.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Rationale: The impact on lung function (LF) and quality of life (QoL) after a severe H1N1 Influenza pneumonia has not been determined.Objective: To describe early abnormalities in LF and QoL according to the severity of pneumonia.Methods: Clinical characteristics, and laboratory samples at the arrival to the emergency room were recorded in 135 patients with H1N1 Influenza moderate to severe pneumonia. LF and health related QoL questionnaires (HRQoL) were measured after two months of hospitalization. All subjects have no clinical antecedent of respiratory disability.Results: Mean age was 40±11 years, 64% were males, Kyrbi Index (KI) was 243±55, the APACHE score was 11.5±5, 30% required mechanical ventilation (MV). 35% had FEV1/FVC <0.70 or >0.85, 31% had PaO2 <60 mmHg; 33% had TLco<85%p, 42% were hypoxemic after 6 Minute Walking Test (6MWT). Four Short-Form 36 (SF-36) domains had ≤70 score and 40% had a Saint George Respiratory Questionnaire (SGRQ) >30 points; 36% had in the SF-36 physical limitation domain (PLSF-36) a score ≤50; Those with MV had more affection in LF in comparison with those without MV (FVC 96±16 vs 104±16%p; TLC 89±12 vs 97±21%p; FEV1/FVC 84±6 vs 81±7; TLco 81±22 vs 96±21%p; 6MWT 431±127 vs 508±97 meters; p<0.05). The HRQoL was worse in MV vs no MV [PLSF-36= 37.5 (0-81) vs 100 (50-100), p<0.05]. KI correlated with TLco (r=0.30), p=0.003; CURB-65 with TLco (r= -0.20), p<0.04. PLSF-36 correlated with TLco (r=0.42), KI (r=0.27) and CURB-65 (r= -0.32), p< 0.02.Conclusions: After a severe pneumonia due to H1N1 influenza, one third of the patients had the LF and HRQoL affected. Patients who required MV had greater impairment in LF and in the HRQoL.