TY - JOUR T1 - Impact of stenotrophomonas maltophilia in cystic fibrosis: A retrospective analysis JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p4293 AU - Elien Dewaele AU - Pieter Goeminne AU - Hans Scheers AU - Lieven Dupont AU - Paul Van den Brande Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p4293.abstract N2 - Introduction: Stenotrophomonas maltophilia (SM) has been isolated more frequently in cystic fibrosis patients (CF) the past few years but the real significance of its presence remains to be elucidated. We investigated the impact of a positive sputum culture with SM on lung disease morbidity in our CF population.Methods: Patients from the CF database were reviewed for presence of SM. Lung function and BMI data were analyzed at 1 y before, at acquisition, at 6 months, 1 and 2 y after acquisition. We compared data between three groups: patients intermittently colonized with SM (IC), chronically colonized (CC) patients and a control group (CG) of CF patients that never acquired SM in their sputum and were matched for gender, age, Pseudomonas status and pancreas insufficiency.Results: Median age was 18 y (IQR 12–25). FEV1% was significantly different between three groups, with lower values in the CC and IC 6 months (p=0.013) before and at time of SM acquisition (p=0.0003). There was no significant difference in lung function evolution between three groups (FEV1% p=0.34, FVC% p=0.24, PEF% p=0.33), but a trend was seen for BMI evolution (p=0.06) with worse BMI over time in the IC (p=0.04) and CC (p=0.06). There was significant increase in # hospitalizations and number of IV courses with antibiotic use after acquisition of SM with highest increase in CC (p=0.04).Conclusion: CF patients with positive sputum culture with SM had worse lung function not only at time of acquisition but also in preceding months. Acquisition of SM was not associated with accelerated FEV1 decline but BMI decreased in patients with SM and exacerbation rate and number of IV antibiotic courses increased after acquisition of SM. ER -