TY - JOUR T1 - Molecular test supporting early lung cancer detection project based on pilot Pomeranian lung cancer screening program JF - European Respiratory Journal JO - Eur Respir J VL - 38 IS - Suppl 55 SP - p2742 AU - Amelia Szymanowska-Narloch AU - Rafal Dziadziuszko AU - Malgorzata Jelitto-Gorska AU - Witold Rzyman Y1 - 2011/09/01 UR - http://erj.ersjournals.com/content/38/Suppl_55/p2742.abstract N2 - Introduction: Lung cancer is one of the most common malignant neoplasms worldwide. Only 10% of patients can be cured, mostly due to late diagnosis and high aggressiveness of lung cancer.Aim: Aim of the Molecular Test Supporting Early Detection of Lung Cancer Project is to perform genetic studies and serum protein studies in order to increase the efficacy of radiological examinations in early lung cancer screening and to define population of particularly high risk of lung cancer development. The project consists of five thematic areas.Results: Pomeranian Pilot Early Detection Program has been realized from the 17th November 2008. In this project 8000 healthy subjects with high risk of developing lung cancer (age 50-75, at least 20 pack-years) were screened with low-dose CT scanning of the lungs. As a co-project blood samples were taken from those patients who gave informed consent. In the first year of project realization 6836 healthy subjects were screened. In above a half of the cases (53%) at least one pathological alteration in lung tissue was found. Among 186 patients, in whom the lesion was above 1 cm in diameter, in 56 cases lung cancer was diagnosed. Almost 60% of lung cancer cases were in stage IA.Conclusions: Pomeranian Pilot Lung Cancer Screening Program and Molecular Test Supporting Early Lung Cancer Screening Project - Moltest 2013 are dedicated to define population of particularly high risk of lung cancer development. ER -