PT  - JOURNAL ARTICLE
AU  - Elena Kremer
AU  - Natalya Kirillova
AU  - Ivan Deev
AU  - Georgij Chernogoruk
AU  - Ludmila Ogorodova
TI  - Various phenotypes of COPD are closely related to regulatory T cells
DP  - 2011 Sep 01
TA  - European Respiratory Journal
PG  - p722
VI  - 38
IP  - Suppl 55
4099  - http://erj.ersjournals.com/content/38/Suppl_55/p722.short
4100  - http://erj.ersjournals.com/content/38/Suppl_55/p722.full
SO  - Eur Respir J2011 Sep 01; 38
AB  - Background: Regulatory T-cells (T-reg) play an important role in physiology and pathology of immune system and take essential place in pathogenesis of various autoimmune, tumoral and allergies diseases. However, T-reg subpopulations in separate phenotypes of COPD remain insufficiently studied.Aim and objectives: To investigate different subpopulations of T-reg in patients with various phenotypes of COPD.Methods: Levels of natural CD4+CD25high and inducible CD4+FoxP3+ T-reg were analyzed in 60 subjects with COPD (including 13 subjects diagnosed with emphysematous phenotype, 28 patients with bronhitich phenotype,19 subjects with mixed phenotype of COPD) and 17 healthy subjects (HS) using the flow cytometry analysis.Results: CD4+CD25high in COPD were significantly increased compared to HS (2,82±0,24%, p = 0,005; 1,56±0,24%, p = 0,005, respectively). Increased level of CD4+CD25high was shown for persons with emphysematous phenotype (3,45±0,40%, p = 0,021) compared to persons diagnosed with bronhitich (2,83±0,22%, p = 0,021) and mixed (2,38±0,22%, p = 0,014) phenotypes of COPD. As for CD4+FoxP3+ T-reg no difference between different phenotypes of COPD and HS was observed.Conclusions: Different subpopulations of T-reg may determine various phenotypes of COPD and this study indicates that increased level of CD4+CD25high is associated with emphysematous phenotype of COPD to support this hypothesis.